Table4.

Protein expression in liver tumor and normal liver of B6C3F1mice treated with carcinogenic PAHs

Pathway	Protein	Tumor (T)	Normal (N)	T/N	P value
DNA repair	ATM	0.590±0.046	0.761±0.126	0.967	0.0432
	pATR	0.569±0.037	0.748±0.019	0.761	0.0001
	Chk1	0.788±0.028	0.961±0.042	0.820	0.0005
	Chk2	1.640±0.128	1.493±0.115	1.098	0.1386
	pChK1	0.743±0.033	0.894±0.017	0.831	0.0002
	DNA PKcs	0.564±0.035	0.772±0.015	0.731	<0.0001
	ERCC1	4.413±0.347	3.450±0.554	1.279	0.0257
	XRCC1	0.508±0.032	0.640±0.011	0.794	0.0002
	FANCD2	1.543±0.093	1.896±0.192	0.814	0.0162
	Ku80	0.585±0.050	0.696±0.027	0.841	0.0081
	MSH2	2.510±0.218	2.274±0.313	1.104	0.2629
	Mre11	0.870±0.040	1.194±0.160	0.729	0.0077
	RAD50	1.465±0.152	1.362±0.166	1.076	0.3985
	Brca2	0.513±0.036	0.680±0.025	0.754	0.0003
Apoptosis	PARP1 (Cleaved)	0.905±0.108	1.105±0.072	0.819	0.0217
	Caspase3	0.363±0.012	0.466±0.015	0.779	<0.0001
	Caspase7 (Cleaved)	0.480±0.024	0.584±0.017	0.822	0.0004
	Bcl-xL	1.501±0.143	1.075±0.056	1.396	0.0014
	Bcl-2	1.301±0.074	1.234±0.136	1.054	0.4207
	Bax	1.485±0.180	0.910±0.015	1.632	0.0007
	pBad(Ser112)	0.988±0.074	0.778±0.031	1.270	0.0019
	XIAP	1.224±0.141	2.495±0.059	0.491	0.0006
Cell cycle regulation	P16/INK4A	1.314±0.117	1.108±0.099	1.186	0.0363
	p53	0.693±0.036	0.884±0.071	0.784	0.0030
	Phopho-Rb (Ser807/811)	0.756±0.043	0.992±0.061	0.762	0.0007
	Rb	1.244±0.087	1.057±0.099	1.177	0.0293
	Cyclin B1	0.726±0.033	1.050±0.030	0.691	<0.0001
	Cyclin D1	0.947±0.068	0.885±0.110	1.070	0.3744
Others	Nrf2	1.013±0.046	1.142±0.030	0.887	0.0034
	Egfr	0.405±0.034	0.455±0.013	0.890	0.0329
	Cox2	0.527±0.029	0.609±0.050	0.865	0.0291

Normal tissues were obtained from control group, n=4.

Tumor tissues were from the BaP group (3 samples) and RM group (1 sample).