Table 3. Comparison of Outcomes Over Time for All Unilateral DBS Cases (Including both STN and GPi).

Variable	Baseline	2-month			4-month			6-month			1-year
		Median, Mean ± SD	Change	p-value	Median, Mean ± SD	Change	p-value	Median, Mean ± SD	Change	p-value	Median, Mean ± SD	Change	p-value
LED	868, 1002±607				1100, 1117±492	96.0, 90.4±352	0.242				1150, 1230±737	208, 228±648	0.068
HAM-A	2.00, 3.00±4.16	4.00, 6.00±5.62	1.50, 3.25±4.99	0.006	5.00, 8.00±7.57	3.50, 5.25±6.78	0.0003	5.00, 8.80±9.90	4.00, 6.05±9.47	0.0009	6.50, 9.70±9.51	5.00, 6.95±9.35	0.0003
HAM-D	1.00, 2.19±2.79	2.00, 3.00±4.40	0, 0.75±3.31	0.403	2.50, 4.10±4.15	1.00, 1.85±3.79	0.028	3.00, 4.40±5.23	1.50, 2.15±5.08	0.027	3.00, 4.55±5.09	2.00, 2.30±5.05	0.017
BDI	6.00, 7.19±4.84				4.50, 7.60±6.34	−1.00, 0.15±5.06	0.960				4.00, 7.20±6.96	−1.00, −0.25±6.13	0.515
AS	10.0, 10.6±6.06				15.0, 14.6±7.62	5.00, 4.32±6.32	0.008				14.0, 13.4±6.70	3.00, 2.84±6.15	0.066
YBOCS	0, 0±0	0, 0.55±2.04	0, 0.55±2.04	0.500	0, 1.20±2.95	0, 1.20±2.95	0.125	0, 1.55±5.21	0, 1.55±5.21	0.250	0, 1.55±5.21	0, 1.55±5.21	0.250
YMRS	0, 0.86±2.20	1.00, 1.65±1.95	0, 0.85±1.95	0.051	1.00, 2.00±2.25	1.00, 1.20±2.31	0.020	1.00, 2.35±2.94	1.00, 1.55±2.48	0.006	1.00, 2.40±2.93	1.00, 1.60±2.50	0.005
UPDRS Motor-Off	39.0, 40.8±10.1				33.0, 32.6±9.68	−9.00, −8.19±7.07	<.0001				32.0, 31.9±11.3	−9.00, −8.90±6.46	<.0001
UPDRS-Motor On	20.0, 21.0±7.97				23.0, 22.2±8.45	2.00, 1.14±6.26	0.468				23.0, 22.7±7.20	2.00, 1.62±5.70	0.205

LED- levodopa equivalent dose; HAM-A- Hamilton Anxiety Inventory; HAM-D- Hamilton Depression Inventory; BDI- Beck Depression Inventory; AS- Apathy Scale; YBOCS- Yale Brown Obsessive Compulsive Scale; YMRS- Young Mania Rating Scale; UPDRS- Unified Parkinson's Disease Rating Scale Motor Section (III); Time intervals correspond to time from the DBS operation. Significant changes are highlighted in bold (p<0.05; and for p<0.01).