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A: Ca++ chelation with 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA-AM) prevented leukotriene D4 (LTD4)-mediated inhibition of Na-alanine cotransport in IEC-18 cells. B: inhibition of PKC pathway with calphostin C and specifically of PKCα with Go-6976 prevented the inhibition of Na-alanine cotransport by LTD4. These data indicated that the increase in intracellular Ca++ seen in LTD4-treated IEC-18 cells activates PKCα and its downstream signaling pathway.
