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LTD4-mediated regulation of Na-alanine cotransport in intestinal epithelial cells. LTD4 regulates ASCT1 activity through 1) PKCα-mediated phosphorylation (P) of ASCT1, 2) cAMP/PKA-mediated phosphorylation of ASCT1, and 3) PKCα mediated phosphorylation of RKIP, leading to the activation of the PKA pathway with eventual regulation of ASCT1.
