Fig. 3.

CSE exposure inhibits IAV induction of the antiviral cytokine protein IP-10 but not the proinfammatory cytokine IL-6 in bronchoalveolar lavage fluid (BALF). Mice were treated with CSE for 6 wk and then infected with 300 pfu of the IAV PR8 strain. All treatments, infections, and appropriate control exposures were administered intratracheally. Antiviral IP-10 (A) and proinfammatory IL-6 (B) cytokine protein levels in BALF harvested 7 days after infection were determined by ELISA. Mock animals were inoculated with PBS. Data are expressed as means ± SE (4 mice/group). *Significant difference between CSE-treated PR8-infected and non-CSE-treated PR8-infected groups, P < 0.05.