Skip to main content
. 2014 Oct 17;307(11):L868–L876. doi: 10.1152/ajplung.00096.2014

Fig. 2.

Fig. 2.

Conditional depletion of SMC EC-SOD augments chronic hypoxic pulmonary hypertension. A: right ventricular systolic pressures (RVSP) measured by direct right ventricle (RV) puncture in KO and CO mice exposed to 35 days of chronic hypobaric hypoxia (Hypo) (395 Torr, equivalent to 18,000 ft or 10% oxygen). Time-matched normoxic mice (Norm) were maintained at Denver ambient altitude for 35 days. Both strains completed tamoxifen treatments 2 wk before the start of the environmental exposure. B: right ventricular hypertrophy (RVH), measured by the ratio of right ventricle/left ventricle + septum weight (RV/LV + septum). There was a significant difference in RVSP and RVH between strains and treatment, determined by 2-way ANOVA. *P < 0.05 vs. CO Norm; #P < 0.05 vs. CO Hypo, n = 7–13.