Table 1.
Normal | Diabetes | Diabetes + l-Arginine | Diabetes + l-Citrulline | |
---|---|---|---|---|
Number of mice/group | 8 | 8 | 7 | 6 |
Body weight, g | 29 ± 1.05 | 18 ± 0.61‡ | 18 ± 0.42‡ | 15 ± 0.33‡ |
Blood glucose, mg/dl | 149 ± 5.37 | 499 ± 0.98* | 495 ± 2.38* | 500 ± 0.5* |
Water consumed, ml/day | 2.29 ± 0.37 | 6.00 ± 0.91* | 7.26 ± 0.48* | 5.18 ± 1.19* |
Average amino acid consumed in drinking water, g·kg−1·day−1 | 0 | 0 | 6.05 | 5.73 |
Average nitrogen consumed in drinking water, mmol·kg−1·day−1 | 0 | 0 | 138.9 | 98.1 |
Systolic blood pressure, mmHg | 122 ± 2.44 | 112 ± 4.03 | 111 ± 4.09 | 109 ± 8.25 |
Percent fluid | 7.5 ± 0.13 | 6.6 ± 0.11* | 5.5 ± 0.17* | 5.8 ± 0.09* |
Kidney weight/body weight, mg/g | 0.92 ± 0.05 | 1.33 ± 0.02* | 1.54 ± 0.03* | 1.53 ± 0.05* |
Plasma creatinine, mg/dl | 0.26 ± 0.08 | 0.62 ± 0.11* | 0.48 ± 0.04* | 0.94 ± 0.16* |
Data are means ± SE. Values were measured 9 wk after streptozotocin treatment.
P < 0.05 compared with the normal group;
P < 0.0001 compared with the normal group.