Fig. 2.

Changes in methylation cycle intermediates and cardiovascular disease (CVD) risk markers homocysteine (Hcy) and S-adenosylhomocysteine (SAH) in serum of ADPKD adults with increasing TKV but preserved eGFR >60 ml·min⁻¹·1.73 m⁻² (A) and comparison between healthy subjects and ADPKD patients with preserved and moderately reduced eGFR (B). Values are means ± SD. Significance levels: *P < 0.05, **P < 0.01, ***P < 0.001 vs. TKV < 800 ml (A) and vs. healthy subjects (B). S-adenosylmethionine (SAM) and SAH are presented in nM, Hcy and methionine (Met) in μM. For significance levels between the ADPKD patients with preserved and moderately reduced eGFR, please refer to Table 4.