Table 2.
Regression analysis of eGFR and serum markers of endothelial dysfunction and oxidative stress/inflammation
| Variable | Model | Estimate ± SE | P Value |
|---|---|---|---|
| ADMA | Unadjusted | −0.36 ± 0.15 | 0.0226 |
| Model 1 | −0.24 ± 0.13 | 0.0678 | |
| Model 2 | −0.23 ± 0.13 | 0.0744 | |
| Arginine | Unadjusted | −0.20 ± 0.09 | 0.0381 |
| Model 1 | −0.21 ± 0.08 | 0.0069 | |
| Model 2 | −0.21 ± 0.08 | 0.0081 | |
| Cysteine | Unadjusted | −0.29 ± 0.11 | 0.0104 |
| Model 1 | −0.13 ± 0.10 | 0.1867 | |
| Model 2 | −0.13 ± 0.10 | 0.1977 | |
| Glutathione | Unadjusted | −0.10 ± 0.03 | 0.0021 |
| Model 1 | −0.05 ± 0.03 | 0.0585 | |
| Model 2 | −0.05 ± 0.03 | 0.0512 | |
| Homocysteine | Unadjusted | −0.60 ± 0.09 | <0.0001 |
| Model 1 | −0.41 ± 0.08 | <0.0001 | |
| Model 2 | −0.42 ± 0.08 | <0.0001 | |
| Methionine | Unadjusted | −0.43 ± 0.04 | <0.0001 |
| Model 1 | −0.34 ± 0.04 | <0.0001 | |
| Model 2 | −0.34 ± 0.04 | <0.0001 | |
| PGD2 | Unadjusted | −0.16 ± 0.02 | <0.0001 |
| Model 1 | −0.11 ± 0.02 | <0.0001 | |
| Model 2 | −0.11 ± 0.02 | <0.0001 | |
| PGE2 | Unadjusted | −0.10 ± 0.04 | 0.0284 |
| Model 1 | −0.04 ± 0.04 | 0.2618 | |
| Model 2 | −0.04 ± 0.04 | 0.2628 | |
| PGF2α | Unadjusted | −0.14 ± 0.03 | <0.0001 |
| Model 1 | −0.08 ± 0.03 | 0.0019 | |
| Model 2 | −0.08 ± 0.03 | 0.0019 | |
| 8-Isoprostane | Unadjusted | −0.10 ± 0.04 | 0.0064 |
| Model 1 | −0.06 ± 0.03 | 0.0744 | |
| Model 2 | −0.06 ± 0.03 | 0.0743 | |
| SAH | Unadjusted | −0.42 ± 0.03 | <0.0001 |
| Model 1 | −0.36 ± 0.03 | <0.0001 | |
| Model 2 | −0.36 ± 0.03 | <0.0001 | |
| SAM | Unadjusted | −0.06 ± 0.08 | 0.4634 |
| Model 1 | −0.11 ± 0.06 | 0.0815 | |
| Model 2 | −0.11 ± 0.06 | 0.0848 | |
| SAM/SAH ratio |
Unadjusted | 0.19 ± 0.02 | <0.0001 |
| Model 1 | 0.15 ± 0.02 | <0.0001 | |
| Model 2 | 0.15 ± 0.02 | <0.0001 | |
| SDMA | Unadjusted | −0.22 ± 0.09 | 0.0134 |
| Model 1 | −0.15 ± 0.07 | 0.0418 | |
| Model 2 | −0.15 ± 0.07 | 0.0497 |
Values are estimate ± SE. See text for definitions. Three models were run for each marker: 1) unadjusted; 2) model 1, adjusted for age and sex; and 3) model 2, adjusted for age, sex, systolic BP, and ln-transformed serum creatinine. P value <0.05 was considered significant and is marked in bold. The variables were ln transformed before analysis.