Fig. 7.

Model of the dynamic interaction among the D₁-like dopamine receptors, α_1A-AR, and ANG II type 1 receptor (AT₁R). The activity of these endogenously expressed receptors is ultimately governed by salt homeostasis. In salt-replete states, natriuretic D₁Rs and D₅Rs, along with ANG II type 2 receptors (not shown), may act cooperatively to inhibit anti-natriuretic α_1A-ARs and AT₁Rs and impede Na⁺-K⁺-ATPase activity via phosphorylation of the catalytic α-subunit and internalization. However, during salt-depleted states, α_1A-ARs and AT₁Rs stimulate Na⁺-K⁺-ATPase activity and overcome the decreased activity of dopamine receptors.