Fig. 4.

Reduced LH in kiss-p110α/β-KO males but normal negative steroid hormone feedback in kiss-p110α/β-KO males and females. Serum LH levels from WT and kiss-p110α/β-KO mice that were intact, gonadectomized (Gdx), and treated with vehicle [Gdx + V for males, ovariectomized (Ovx) + V for females] or Gdx and treated with steroid hormone [Gdx + testosterone (T) for males, Ovx + estradiol (E₂) for females] for 10 days (n = 6–10 mice/treatment/genotype). A: a significant genotype and treatment effect on LH levels was observed in males (2-way ANOVA). B: a significant treatment effect but no genotype effect on LH levels was observed in females (2-way ANOVA). No genotype effect on LH levels was observed in females from each treatment group. Values are means ± SE. *P <0.05 vs. WT; **P <0.001 vs. Gdx + V.