Fig. 3.

Both plasma and tissue levels of H₄B increase with folic acid (FA) treatment in ANG II-infused apoE null and hph-1 mice. H₄B levels were determined in plasma and aortas from apoE null mice (A; n = 4–5 each) and hph-1 mice (B; n = 4 each) at baseline and then weekly for 4 or 2 wk, respectively, after ANG II and FA treatment. Results show that FA treatment was able to significantly increase plasma and tissue H₄B levels in both mouse models of AAA, up to the end of the experimental protocol. *P < 0.05 vs. baseline.