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. 2014 Dec 3;9(12):e114635. doi: 10.1371/journal.pone.0114635

Table 2. Articular diseases, symptoms and medication predicted by chronotype.a .

Chronotype Odds ratio 95% confidence limit
Lower Upper
Rheumatoid arthritis diagnosed or treated by doctor in the past 12 months
Model 1 (N = 6074, No N = 5988, Yes N = 86)
Evening-types 0.6 0.2 1.5
Intermediate-types 1.7 1.1 2.6*
Model 2 (N = 6074, No N = 5988, Yes N = 86)
Evening-types 0.9 0.3 2.2
Intermediate-types 2.0 1.3 3.1**
Model 3 (N = 5954, No N = 5873, Yes N = 81)
Evening-types 0.9 0.3 2.4
Intermediate-types 2.0 1.3 3.3**
Rheumatic symptoms past month
Model 1(N = 6079, No N = 5632, Yes N = 447)
Evening-types 1.2 0.9 1.6
Intermediate-types 1.1 0.9 1.3
Model 2 (N = 6079, No N = 5632, Yes N = 447)
Evening-types 1.7 1.2 2.2**
Intermediate-types 1.2 1.0 1.5
Model 3 (N = 5961, No N = 5527, Yes N = 434)
Evening-types 1.6 1.1 2.2**
Intermediate-types 1.2 0.9 1.5
Articular pain past month
Model 1(N = 6074, No N = 4167, Yes N = 1907)
Evening-types 0.9 0.8 1.1
Intermediate-types 0.9 0.8 1.0*
Model 2 (N = 6074, No N = 4167, Yes N = 1907)
Evening-types 1.3 1.1 1.5*
Intermediate-types 1.0 0.9 1.2
Model 3 (N = 5956, No N = 4093, Yes N = 1863)
Evening-types 1.3 2.0 1.5*
Intermediate-types 1.0 0.9 1.2
Other articular disease diagnosed or treated by doctor in the past 12 months
Model 1 (N = 6063, No N = 5444, Yes N = 619)
Evening-types 0.9 0.7 1.1
Intermediate-types 0.8 0.7 1.0*
Model 2 (N = 6063, No N = 5444 Yes N = 619)
Evening-types 1.3 1.0 1.8*
Intermediate-types 1.0 0.8 1.2
Model 3 (N = 5944, No N = 5337, Yes N = 607)
Evening-types 1.4 1.0 1.8*
Intermediate-types 1.0 0.8 1.2
Medication for articular pain
Model 1 (N = 5967, No N = 1577, Yes N = 4390)
Evening-types 1.1 0.9 1.4
Intermediate-types 1.0 0.9 1.2
Model 2 (N = 5967, No N = 1577, Yes N = 4390)
Evening-types 1.2 1.0 1.5
Intermediate-types 1.1 0.9 1.2
Model 3 (N = 5858, No N = 1545, Yes N = 4313)
Evening-types 1.3 1.0 1.5*
Intermediate-types 1.1 0.9 1.2
a

Model 1 crude (univariate); model 2 controlled for gender and age; model 3 controlled for gender, age, education level, civil status, physical activity, alcohol consumption, and current smoking. Morning-types as the reference category. * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001.