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. 2014 Dec 3;9(12):e114393. doi: 10.1371/journal.pone.0114393

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© 2014 Nijmeijer et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A - Representative pancreatic histology following induction of acute pancreatitis (H&E staining, 20x and 100x consecutive magnifications for each experimental group): wild-type control (a,b); wild-type acute pancreatitis (c,d); Fxr^-/- control (e,f); Fxr^-/- acute pancreatitis (g,h). B – Semi-quantitative composite pancreatitis severity score of histopathological examination of pancreas samples from wild-type and Fxr^-/- mice with and without acute pancreatitis. Absence of Fxr does not result in more severe acute pancreatitis. C – Ileal mRNA expression of Fgf15 in wild-type and Fxr^-/- mice with and without early acute pancreatitis. Fgf15 expression was decreased in wild-type mice with acute pancreatitis. Bars indicate mean and SEM.