. 2014 Dec 17;88:89–100. doi: 10.1016/j.ejmech.2014.08.060

Table 2.

IC₅₀ values of thienopyridone, the rhodanine control and compounds 1 and 2 from in silico screens, obtained by in vitro DiFMUP dephosphorylation (see the Experimental section). ID of the ZINC database [33] and screening origin are indicated.

Compound	IC₅₀ [μM]			Origin of hit	ZINC-ID
PRL-3	PRL-2	PRL-1
Thienopyridone	0.24 ± 0.13	0.24 ± 0.00	0.26 ± 0.03	Positive control [17]
Rhodanine	53 ± 10	27 ± 7	35 ± 14	Positive control [13]	970452
1	48 ± 13	104 ± 15	70 ± 20	USR screen	6947664
2	102 ± 26	188 ± 39	209 ± 81	USR screen	20347422