Table 2.

Association of Sclerostin Levels With Bone and Body Composition Parameters in Men

	Adjusted Meana Sclerostin Tertiles			P Valueb
	Low	Middle	High	Age Adjusted	Multivariable Adjusteda
Sclerostin, ng/mL, range	0.60–1.03	1.04–1.39	1.40–2.87
Spine
Trabecular vBMD, g/cm3	0.07	0.07	0.08	.03c	.10c
Integral vBMD, g/cm3	0.18	0.19	0.20	<.01c	<.01c
Compressive strength, kN	0.16	0.19	0.21	.01c	.06c
CSA, mm2	11.9	11.8	12.3	.27	.37
aBMD, g/cm2	1.20	1.32	1.36	<.01c	<.01c
Femoral neck
Trabecular vBMD, g/cm3	0.10	0.11	0.13	<.01	<.01
Cortical vBMD, g/cm3	0.48	0.48	0.49	.14	.11
Integral vBMD, g/cm3	0.20	0.21	0.24	<.01	<.01
aBMD, g/cm2	0.81	0.87	0.94	<.01	<.01
Total hip
Trabecular vBMD, g/cm3	0.13	0.14	0.16	<.01	<.01
Cortical vBMD, g/cm3	0.46	0.48	0.49	<.01c	<.01c
Integral vBMD, g/cm3	0.20	0.21	0.23	<.01	<.01
aBMD, g/cm2	0.88	0.93	1.01	<.01c	<.01c
Bone turnover markers
P1NP, ng/mL	48.7	41.6	45.3	.38	.58
CTX, ng/mL	0.58	0.46	0.55	.10	.91
Body composition
Weight, kga	82.0	81.6	86.5	.04	.03
BMI, kg/m2a	27.4	26.9	28.2	.15	.19
Total lean mass by DXA, kg	52.0	51.8	52.7	.48	.65
Total fat by DXA, kg	26.4	27.6	28.1	.03	.04
Abdominal visceral fat, g	183.5	197.7	200.6	.08	.24
Abdominal sc fat, g	195.9	204.2	206.5	.02	.07
Muscle attenuation, HU	42.4	40.8	41.6	.40	.61

^aAdjusted for age, diabetes status, and BMI, except weight and BMI are adjusted for age and diabetes status.

^bP value for sclerostin as a continuous variable in linear regression.

^cEvidence of nonlinearity (P value for joint effect of two spline components).