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Responses to multiple boluses kisspeptin in a male (♂) and a female (♀) subject with Kallmann syndrome (KS) and evidence of endogenous GnRH neuronal activity. Arrows indicate times of boluses. Note escalating doses of kisspeptin provided to subject 9. T, testosterone; E2, estradiol levels during the study. FSH values measured from the first 2-h pool.
