Figure 5.

Intact responses to kisspeptin in a male (♂) subject with reversal of IHH. Both studies were performed without pituitary priming. The left panel shows the single bolus protocol and demonstrates the presence of endogenous pulsatile LH secretion and a response to kisspeptin. The right panel shows the study performed with multiple kisspeptin boluses and demonstrates consistent pulses of LH secretion in response to kisspeptin. Dashed lines mark the times kisspeptin or GnRH were given. T, testosterone levels during the study. FSH values measured from the first 2-h pool.