Table 2.
Logistic Regression Model for Miscarriage Risk in Relation to Plasma Kisspeptin in Women During the Antenatal Booking Visit
| Parameter | Unadjusted Model 1 | Adjusted |
|
|---|---|---|---|
| Model 2 | Model 3 | ||
| (Log) Kisspeptin | 0.11 (0.07, 0.17) P < .0001 | 0.14 (0.08, 0.22) P < .0001 | 0.13 (0.08, 0.22) P < .0001 |
| Age | 1.02 (0.94, 1.11) P = .627 | 1.03 (0.94, 1.12) P = .565 | |
| BMI | 0.96 (0.88, 1.05) P = .406 | 0.97 (0.89, 1.07) P = .559 | |
| Gestational age | 0.72 (0.55, 0.95) P = .019 | 0.68 (0.51, 0.91) P = .010 | |
| Smoking | 1.31 (0.24, 7.23) P = .755 | 1.23 (0.22, 6.78) P = .811 | |
| Diastolic BP | 0.99 (0.93, 1.05) P = .649 | ||
| Systolic BP | 0.99 (0.96, 1.03) P = .771 | ||
The unadjusted odds of experiencing a miscarriage decrease by 89% (OR 0.11; 95% CI 0.07–0.17; P = .0001) for each unit increase in (log) plasma kisspeptin. After adjusting the model by age, gestational age (weeks), and BMI, we found that the effects of kisspeptin change slightly. After adjustment for confounders, the odds of experiencing a miscarriage still decrease by 87% (OR 0.13; 95% CI 0.08–0.22; P = .0001) for each unit increase in (log) kisspeptin.