. Author manuscript; available in PMC: 2015 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2014 Oct 31;281(3):254–265. doi: 10.1016/j.taap.2014.10.009

Table 9.

Summary of Oximes Challenged with Paraoxon

Oxime Dose	Oxime	Oxime Dose (mg/kg)	24-hr Lethality	24-hr Mean QOL Score	24-hr Mean RA_AChE (%)	24-hr Mean RA_BChE (%)
Equimolar	2 PAM Cl	25.7	0/8^*	0.1^*	49^*	45^*
	HLö7 DMS	75.9	0/8^*	1.0^*	38	30
	Obidoxime	52.3	1/8^*	1.5^*	80^*	47^*
	MMB4 DMS	65.3	1/8^*	2.3^*	71^*	52^*
	HI-6 DMS	69.6	1/8^*	3.3^*	25	19
	TMB4	15.8	2/8^*	4.9^*	52^*	31
	MINA	12.7	7/8	11.3	16	14
	RS194B	31	8/8	12.0	-	-
	none	0.0	54/64 = 84%	10.8^†	23	21

Therapeutic	MMB4 DMS	104	0/8^*	0.0^*	35	22
	HI-6 DMS	110	5/8	8.6	26	19
	RS194B	126	5/8	7.6	16	11
	MINA	33.2	7/8	11.3	5	4
	none	0.0	28/32 = 88%	11.1^‡	13	7

Statistically significant at the 0.05 level compared to the control group

^†

pooled across 64 animals challenged as equimolar controls with paraoxon

^‡

pooled across 32 animals challenged as TI controls with paraoxon