Table 10.
Summary of Oximes Challenged with Phorate oxon
| Oxime Dose | Oxime | Oxime Dose (mg/kg) | 24-hr Lethality | 24-hr Mean QOL Score | 24-hr Mean RAAChE (%) | 24-hr Mean RABChE (%) |
|---|---|---|---|---|---|---|
| Equimolar | HLö7 DMS | 75.9 | 0/8* | 0.1* | 64* | 61 |
| Obidoxime | 52.3 | 0/8* | 1.1* | 75* | 48 | |
| 2 PAM Cl | 25.7 | 1/8* | 1.5* | 48 | 50 | |
| MMB4 DMS | 65.3 | 2/8* | 3.0* | 64* | 55 | |
| TMB4 | 15.8 | 6/8 | 9.6 | 67* | 52 | |
| HI-6 DMS | 69.6 | 7/8 | 10.6 | 48 | 44 | |
| RS194B | 31 | 7/8 | 11.3 | 47 | 49 | |
| MINA | 12.7 | 8/8 | 12.0 | - | - | |
| none | 0.0 | 62/64 = 97% | 11.8† | 32 | 36 | |
|
| ||||||
| Therapeutic | MMB4 DMS | 104 | 1/8* | 1.5* | 82 | 56 |
| HI-6 DMS | 110 | 5/8 | 8.3 | 50 | 43 | |
| RS194B | 126 | 7/8 | 10.5 | 52 | 53 | |
| MINA | 33.2 | 8/8 | 12.0 | - | - | |
| none | 0.0 | 32/32 = 100% | 12.0 | - | - | |
*
Statistically significant at the 0.05 level compared to the control group
†
pooled across 64 animals challenged as equimolar controls with phorate oxon