. Author manuscript; available in PMC: 2015 Dec 15.

Published in final edited form as: Bioorg Med Chem Lett. 2014 Oct 2;24(24):5840–5844. doi: 10.1016/j.bmcl.2014.09.067

Table 1.

Corrector activity, Vmax, and cLogP data for bisazoles.

1	EC₅₀(μM)^a = 0.87 V_max(μM/s)^b = 97.97 CLogP = 5.60
2a′	EC₅₀(μM)^a = not active V_max(μM/s)^b = not active CLogP = 3.95
2b	EC₅₀(μM)^a = 0.74 V_max(μM/s)^b = 84.46 CLogP = 5.20
2c	EC₅₀(μM)^a = 0.66 V_max(μM/s)^b = 65.00 CLogP = 4.39
2d	EC₅₀(μM)^a = not active V_max(μM/s)^b = not active CLogP = 5.04
2e	EC₅₀(μM)^a = 0.59 V_max(μM/s)^b = 35.46 CLogP = 4.39
23	EC₅₀(μM)^a = not active V_max(μM/s)^b = not active CLogP = 5.60

Concentration where the increased I⁻ influx is 50% of Vmax.

Vmax is the maximum increase in I⁻ influx due to compound dosing.