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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Microbiol Spectr. 2014 Aug 15;2(4):14. doi: 10.1128/microbiolspec.MGM2-0021-2013

Table 1.

Mtb H37Rv genes involved or thought to be involved in the biogenesis of phospholipids, triglycerides, isoprenoids and related lipidsa.

Rv
number		 Gene
name		 Function Evidence Reference
Rv0221 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv0308 - Putative phosphatidic acid phosphatase H [20]
Rv0436c pssA Putative phosphatidylserine synthase P,H [25]
Rv0437c psd Putative phosphatidylserine decarboxylase H -
Rv0534c menA Demethylmenaquinone synthase E [114]
Rv0542c menE o-succinylbenzoyl-CoA synthase E [111– 113]
Rv0548c menB 1,4-dihydroxy2-napthoic acid synthase E [108– 110]
Rv0562 - ω,E,E,E-geranylgeranyldiphosphate synthase E [87]
Rv0564c gpdA1 Putative glycerol-3-phosphate synthase H -
Rv0654 - Carotenoid oxygenase E [132]
Rv0895 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv0989c - Geranyldiphosphate synthase E [85]
Rv1011 ispE 4-Diphosphocytidyl-2C-methyl-D-erythritol kinase E [61, 62]
Rv1086 - ω,E,Z-farnesyldiphosphate synthase E [79, 80]
Rv1159 pimE Polyprenol phosphomannose-dependent α-1,2-mannosyltransferase E,P [34]
Rv1411c lprG Lipoprotein; putative PIM, LM and LAM transporter P [38]
Rv1425 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv1551 plsB1 Putative glycerol-3-phosphate acyltransferase H -
Rv1760 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv1822 pgsA2 Putative cardiolipin synthase H -
Rv2188c pimB’ GDP-Man-dependent α-1,6-phosphatidylinositol mannosyltransferase E,P [31]
Rv2267c stf3 Putative sulfotransferase P,H [117]
Rv2285 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv2361c - ω,E,poly-Z-decaprenyldiphosphate synthase E [83]
Rv2482c plsB2 Putative glycerol-3-phosphate acyltransferase H -
Rv2483c plsC Putative lysophosphatidate acyltransferase H -
Rv2484c - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv2524c fas Fatty acid synthetase type I E,P [17, 18]
Rv2610c pimA GDP-Man-dependent α-1,2-phosphatidylinositol mannosyltransferase E,P [28, 30]
Rv2611c - Acyltransferase involved in the 6-O-acylation of the Manp residue linked to the 2-position of myo-inositol in PIM1 and PIM2 E,P [32]
Rv2612c pgsA1 Phosphatidyl-myo-inositol synthase and/or phosphatidyl-myo-inositol phosphate synthase E,P [25, 26]
Rv2682c dxs 1-deoxy-D-xylulose-5-phosphate synthase E [49]
Rv2746c pgsA3 Phosphatidylglycerophosphate synthase P,H [25]
Rv2868c ispG 1-hydroxy-2-methyl-2(E)-butenyl 4-diphosphate synthase H [50]
Rv2870c ispC 1-Deoxy-D-xylulose 5-phosphate reductoisomerase E [54, 55]
Rv2881c cdsA Putative CDP-diacylglycerol synthase H [23]
Rv2982c gpdA2 Putative glycerol-3-phosphate synthase H -
Rv3087 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3088 tgs4 Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3130c tgs1 Acyl-CoA:diacylglycerol acyltransferase E,P [15, 21]
Rv3233c - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3234c tgs3 Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3371 - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3377c - Tuberculosinyldiphosphate synthase E [138]
Rv3378c - Isotuberculosinol synthase E [135, 139, 140]
Rv3383c - ω,E,E,E-geranylgeranyldiphosphate synthase E [87]
Rv3398c - ω,E,E-farnesyldiphosphate synthase E [86]
Rv3480c - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3581c ispF 2C-methyl-D-erythritol 2,4-cyclodiphosphate E [63]
Rv3582c ispD 4-diphosphocytidyl-2C-methyl-D-erythritol E [58]
Rv3734c tgs2 Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3740c - Putative acyl-CoA:diacylglycerol acyltransferase E [15]
Rv3804c fbpA Acyl-CoA:diacylglycerol acyltransferase E,P [22]
a

The experimental evidence for the annotation of a gene may either be ‘enzymatic’ (E) (i.e., an enzymatic activity was associated to the gene’s product in vitro) or ‘phenotypic’ (P) (i.e., the annotation results from the biochemical analysis of mycobacterial recombinant strains – e.g., knock-out/knock-down mutants, complemented mutant strains, overexpressors - or from the functional complementation of defined E. coli mutants). In some cases, the function of a gene is exclusively based on its homology to other known (myco)bacterial genes (H).

HHS Vulnerability Disclosure