Table 2. The detailed characteristics of all eligible studies for MTHFR A1298C polymorphism.
| MTHFR A1298C | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Children | Mother | |||||||||||||||||
| Cases | Controls | Cases | Controls | |||||||||||||||
| Study | Year | Country (Ethnicity **) | AA | AC | CC | AA | AC | CC | HWE | AA | AC | CC | AA | AC | CC | HWE | Methods | Main types of CHD * |
| Storti et al | 2003 | Italy (C) | 45 | 47 | 11 | 101 | 86 | 13 | 0.387 | 49 | 46 | 8 | 101 | 86 | 13 | 0.387 | PCR-RFLP | VSD,TOF, DORV, PA, d-TGA, AC |
| Nurk et al | 2004 | Norway (C) | — | — | — | — | — | — | — | 9 | 13 | 3 | 6607 | 6342 | 1525 | 0.955 | RT-PCR | Congenital Anomalies Heart |
| Galdieri et al | 2007 | Brazil (M) | 35 | 21 | 1 | 19 | 16 | 3 | 1.000 | 26 | 17 | 4 | 15 | 10 | 1 | 1.000 | PCR-RFLP | Congenital Heart Defects |
| van Driel et al | 2008 | Netherlands (C) | 112 | 90 | 27 | 97 | 129 | 25 | 0.073 | 104 | 102 | 24 | 116 | 104 | 31 | 0.319 | PCR-RFLP | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS, |
| Obermann-Borst et al | 2010 | Netherlands (C) | 69 | 57 | 13 | 75 | 90 | 18 | 0.256 | — | — | — | — | — | — | — | PCR-RFLP | TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS |
| Xu et al | 2010 | China (A) | 316 | 168 | 18 | 326 | 185 | 16 | 0.110 | — | — | — | — | — | — | — | PCR-RFLP | Cyanotic Cardiac Disease, ASD, VSD, PDA, Left-sided Obstruction Defects. |
| Weiner et al | 2012 | Russia (C) | — | — | — | — | — | — | — | 33 | 13 | 2 | 168 | 152 | 42 | 0.403 | RT-PCR | Congenital Anomalies-cardiovascular System |
| Wang et al | 2013 | China (A) | 115 | 45 | 10 | 133 | 47 | 8 | 0.186 | — | — | — | — | — | — | — | SEQUENCE | Congenital Heart Disease |
| Sahiner et al | 2013 | Turkey (C) | 45 | 68 | 24 | 31 | 54 | 8 | 0.029 | — | — | — | — | — | — | — | PCR-RFLP | Obstruction in LV Output, Left-to-right Shunt, Conotruncal Anomalies, Complex Anomalies |
| Zidan et al | 2013 | Egypt (AR) | 16 | 27 | 37 | 26 | 24 | 27 | 0.001 | 13 | 32 | 25 | 33 | 25 | 22 | 0.001 | PCR-RFLP | ASD, VSD, PDA, PS, TOF, HLHS, Combined lesion |
| Christensen et al *** | 2013 | USA (C) | 78 | 67 | 12 | 38 | 26 | 5 | 0.764 | 98 | 71 | 13 | 36 | 22 | 7 | 0.220 | PCR-RFLP | VSD, TOF, AS, TGA, AVSD, DORV, PS, CoA, Truncus Arteriosus |
| Huang et al | 2014 | China (A) | 111 | 56 | 3 | 146 | 56 | 6 | 0.800 | — | — | — | — | — | — | — | MS | TOF |
*: PS: Pulmonary Stenosis; HLHS: Hypoplastic Left Heart Syndrome; CoA: Coarctation of the Aorta; TGA: Transposition of Great Arteries; ASD: Atrial Septal Defect; VSD: Ventricular Septal Defect; AVSD: Atrioventricular Septal Defect; TOF: Tetralogy of Fallot; PDA: Patent Ductus Arteriosus; PA: Pulmonary Atresia; DORV: Double-outlet Right Ventricle; AC: Aortic Coarctation; AS: Aortic Stenosis.
**: C: Caucasians; A: South Asians; M: Mixed; AR: Arabian.
***: The data was respectively provided by author of Dr. Karen E. Christensen (see Acknowledgements).