Table 3. Main results of association between MTHFR C677T polymorphism and CHD.
| Sample size | Test of heterogeneity | Test of association | Test of publication bias | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subgroup | Genetic model | Patients | Controls | Q | P | I2 (%) | OR | 95% CI | Z | P | z | P |
| Children Overall | T vs. C | 9,329 | 15,076 | 146.67 | 0.000 | 82.3 | 1.248 | 1.093–1.426 | 3.27 | 0.001 | 1.13 | 0.260 |
| TT vs. CC | 118.35 | 0.000 | 78.9 | 1.485 | 1.140–1.935 | 2.93 | 0.003 | 0.48 | 0.628 | |||
| TT vs. CT | 53.62 | 0.001 | 53.4 | 1.312 | 1.100–1.565 | 3.02 | 0.003 | 0.66 | 0.508 | |||
| Dominant model | 102.79 | 0.000 | 74.4 | 1.240 | 1.053–1.461 | 2.58 | 0.010 | 1.54 | 0.123 | |||
| Recessive model | 89.82 | 0.000 | 72.2 | 1.401 | 1.139–1.724 | 3.19 | 0.001 | 0.18 | 0.860 | |||
| Maternal Overall | T vs. C | 3,232 | 2,7174 | 34.32 | 0.011 | 47.6 | 1.215 | 1.085–1.361 | 3.38 | 0.001 | 0.35 | 0.726 |
| TT vs. CC | 32.94 | 0.017 | 45.4 | 1.488 | 1.169–1.895 | 3.23 | 0.001 | 1.33 | 0.174 | |||
| TT vs. CT | 35.13 | 0.009 | 48.8 | 1.315 | 1.042–1.659 | 2.31 | 0.021 | 0.98 | 0.327 | |||
| Dominant model | 25.69 | 0.107 | 29.9 | 1.258 | 1.144–1.383 | 4.74 | 2.14e-6 | 0.70 | 0.484 | |||
| Recessive model | 35.86 | 0.007 | 49.8 | 1.408 | 1.128–1.757 | 3.03 | 0.002 | 0.91 | 0.363 | |||
| Caucasian Children | T vs. C | 7,092 | 12,150 | 26.94 | 0.003 | 62.9 | 1.163 | 1.008–1.342 | 2.06 | 0.039 | 2.18 | 0.029 |
| TT vs. CC | 18.09 | 0.073 | 44.7 | 1.273 | 0.978–1.658 | 1.79 | 0.073 | 0.93 | 0.350 | |||
| TT vs. CT | 9.29 | 0.505 | 0.0 | 0.986 | 0.892–1.090 | 0.28 | 0.781 | 0.62 | 0.533 | |||
| Dominant model | 24.13 | 0.007 | 58.6 | 1.182 | 0.982–1.422 | 1.77 | 0.077 | 2.34 | 0.020 | |||
| Recessive model | 13.12 | 0.217 | 23.8 | 1.012 | 0.921–1.113 | 0.26 | 0.798 | 0.47 | 0.640 | |||
| Caucasian Maternal | T vs. C | 2,431 | 26,170 | 9.22 | 0.417 | 2.4 | 1.125 | 1.043–1.214 | 3.04 | 0.002 | 0.89 | 0.371 |
| TT vs. CC | 7.25 | 0.611 | 0.0 | 1.157 | 0.977–1.370 | 1.69 | 0.690 | 0.72 | 0.474 | |||
| TT vs. CT | 6.95 | 0.643 | 0.0 | 0.945 | 0.800–1.116 | 0.67 | 0.504 | 0.00 | 1.00 | |||
| Dominant model | 11.03 | 0.274 | 18.4 | 1.216 | 1.096–1.348 | 3.69 | 2.24e-4 | 0.54 | 0.592 | |||
| Recessive model | 6.58 | 0.681 | 0.0 | 1.074 | 0.894–1.227 | 0.57 | 0.566 | 0.54 | 0.592 | |||
| Asian Children | T vs. C | 1,911 | 2,222 | 74.39 | 0.000 | 86.6 | 1.449 | 1.117–1.880 | 2.79 | 0.005 | 0.16 | 0.876 |
| TT vs. CC | 62.4 | 0.000 | 83.9 | 1.960 | 1.203–3.192 | 2.70 | 0.007 | 0.16 | 0.876 | |||
| TT vs. CT | 31.57 | 0.000 | 68.3 | 1.649 | 1.209–2.248 | 3.16 | 0.002 | 0.47 | 0.640 | |||
| Dominant model | 43.94 | 0.000 | 77.2 | 1.441 | 1.049–1.978 | 2.26 | 0.024 | 0.16 | 0.876 | |||
| Recessive model | 49.87 | 0.000 | 79.9 | 1.761 | 1.227–2.526 | 3.07 | 0.002 | 0.62 | 0.533 | |||
| Asian Maternal | T vs. C | 467 | 616 | 3.96 | 0.412 | 0.0 | 1.595 | 1.348–1.886 | 5.45 | 5.04e-8 | – | – |
| TT vs. CC | 3.49 | 0.479 | 0.0 | 2.548 | 1.788–3.631 | 5.18 | 2.22e-7 | – | – | |||
| TT vs. CT | 1.51 | 0.825 | 0.0 | 1.884 | 1.415–2.509 | 4.34 | 1.42e-5 | – | – | |||
| Dominant model | 4.93 | 0.295 | 18.9 | 1.605 | 1.215–2.121 | 3.33 | 0.001 | – | – | |||
| Recessive model | 2.05 | 0.727 | 0.0 | 2.073 | 1.583–2.716 | 5.29 | 1.22e-7 | – | – | |||