Figure 3.

Matrix stiffness-coupled lamin A and MYH9 turnover. (A) Cytoskeletal myosin and nucleoskeletal lamin A is coupled where each regulates their own message and follows a tension-inhibited degradation mechanism. Lamin A has also been shown to regulate SRF-target genes (α₃), such as MYH9 (4). (B) Kinetics (top) and steady-state (bottom) myosin (m) and lamin A (l) protein levels, assuming α₃ = 0, at low (E = 0.005) or high (E = 0.4) tension. (C) With feedback of lamin A on myosin transcription (α₃ > 0), both myosin and lamin levels are increased. To see this figure in color, go online.