Figure 8. Model for transcriptional interference at tgp1⁺.

The presence of phosphate induces transcription of an unstable lncRNA (nc-tgp1). lncRNA transcription increases nucleosome density, occludes Pho7 transcription factor binding and thus represses tgp1⁺ expression. nc-tgp1 transcription is reduced following phosphate starvation, decreasing nucleosome density, allowing Pho7 to stably engage the tgp1⁺ promoter and induce tgp1⁺ expression.