Extended Data Figure 3.

Metabolic labelling of CAC and proximal metabolites by ¹³C glucose in the ischaemic and normoxic myocardium. Proportional isotopic labelling profile of CAC and proximal metabolites during normoxic and ischaemic myocardial perfusion. Mouse hearts were perfused with 11 mM ¹³C glucose for 10 min followed by either 30 min no flow ischaemia or 30 min normoxic perfusion followed by snap-freezing and LC-MS metabolomic analysis (n = 4). * p < 0.05, ** p < 0.01, *** p < 0.001. Data are shown as the mean ± s.e.m of at least four biological replicates.