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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Acta Neuropathol. 2013 Dec 24;127(1):29–51. doi: 10.1007/s00401-013-1230-6

Fig. 1.

Fig. 1

The neuropathology of acute concussive injury. a Axonal swelling in the corpus callosum (Table 1, case 2), APP immunostaining, 10 m-paraffin section. b Perivascular clusters of activated microglia in the corpus callosum and subcortical white matter (Table 1, case 1), LN3 immunostain, 50 mm free-floating section. c Vascular amyloid in leptomeningeal vessel (Table 1, case 6), Ab 42 immunostain, 10 m paraffin section. d Persistent axonal swelling in the cerebellar white matter (Table 1, case 6), APP immunostain, 10 m paraffin section. e Perivascular microglia around deep white matter vessel (Table 1, case 3), 50 mm free-floating section. f Hemosiderin-laden macrophages around a small blood vessel indicating a remote microbleed (asterisk) in close proximity to focal PHF-tau NFTs and neurites in the uncus (arrowhead) (Table 1, case 5). AT8 immunostain with hematoxylin counterstain, 10 m paraffin section. g Perivascular axonal spheroid in the cerebellar white matter (Table 1, case 6). APP immunostain, 10 m paraffin section. h Perivascular reactive astrocytes in white matter (Table 1, case 3), GFAP immunostain, 10 m paraffin section. i PHF-tau immunoreactive neurites in the medulla (Table 1, case 3), AT8 immunostain, 50 mm free-floating section. j Axonal swelling with digestion chamber in the midbrain tegmentum (Table 1, case 5), SMI 34 immunostain, 10 m-paraffin section. k Perivascular reactive astrocytes in white matter (Table 1, case 2), GFAP immunostaining, 10 m-paraffin section. l PHF-tau immunoreactive NFTs in the reticular formation of the medulla (Table 1, case 3), AT8 immunostain, 50 mm free-floating section. m Perivascular axonal swellings (arrowhead) (Table 1, case 2), APP immunostaining, 10 m-paraffin section. n TDP-43 immunoreactive neurites in the fornix (arrowheads) (Table 1, case 1), TDP-43 immunostain, 50 mm free-floating section. o PHF-tau immunoreactive perivascular NFTs and neurites in the frontal cortex (Table 1, case 3), AT8 immunostain, 50 mm free-floating section. All magnification bars 100 mm