. 2013 Dec 19;135(2):319–334. doi: 10.1002/ijc.28684

Table 1.

DNA methylation alterations during lung carcinogenesis

The number of probes showing DNA hypermethylation and DNA hypomethylation
(A) The probes on which DNA methylation levels were altered in 139 samples of non-cancerous lung tissue (N) obtained from patients with lung adenocarcinomas (LADCs) in the learning cohort relative to those in 39 samples of normal lung tissue (C) obtained from patients without any primary lung tumors. (Welch's t-test, False discovery rate [FDR] q = 0.01)
DNA hypermethylation (β_C < β_N)	1,526
DNA hypomethylation (β_C > β_N)	2,252
Total	3,778
(B) The probes on which DNA methylation levels showed ordered differences from 39 C samples to 139 N samples, and then to 139 tumorous tissue (T) samples in the learning cohort. (Jonckheere–Terpstra trend test, FDR q = 0.01)
DNA hypermethylation (β_C < β_N < β_T, β_C < β_N ≒ β_T or β_C≒ β_N < β_T)	6,460
DNA hypomethylation (β_C > β_N > β_T, β_C > β_N ≒ β_T or β_C ≒ β_N > β_T)	5,908
Total	12,368
(C) The probes satisfying both of the above criteria (A) and (B): DNA methylation alterations on these probes occurred even in N samples relative to C samples, and such DNA methylation alterations were inherited by, or strengthened in, T samples.
DNA hypermethylation (β_C < β_N < β_T or β_C < β_N ≒ β_T)	484
DNA hypomethylation (β_C > β_N > β_T or β_C > β_N ≒ β_T)	1,444
Total	1,928