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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Cell Rep. 2014 Oct 23;9(3):1135–1150. doi: 10.1016/j.celrep.2014.09.042

Figure 7. The Chaperome Sub-Network as Proteostasis Safeguard and its Collapse in Disease.

Figure 7

A. Chaperome sub-network action as buffer that safeguards proteostasis from proteotoxic stress, facilitating healthy development and aging. B. Chaperome sub-network perturbation entails proteostasis collapse, exposure to proteotoxicity, accelerated aging and age-onset disease. Perturbation exemplified by loss of edges and repression of gene expression (green nodes).