Table 2.
Association between clinical variables and the presence of CKD signs or hypertension (n=169)
| Clinical Variable | Non-CKD (n=115) | CKD or Hypertension (n=54) | P |
|---|---|---|---|
| Gestational age, wk | 40.0 (38.6–41.1) | 39.7 (39.0–41.0) | 0.63a |
| Diagnosis | |||
| Meconium aspiration syndrome | 62 (54) | 25 (46) | 0.87b |
| Congenital diaphragmatic hernia | 22 (19) | 14 (26) | |
| Isolated persistent pulmonary | 14 (12) | 7 (13) | |
| Sepsis | 6 (5) | 3 (6) | |
| Other | 11 (10) | 5 (9) | |
| Pre-ECMO | |||
| Age at start ECMO, h | 41 (26–74) | 43 (31–74) | 0.50a |
| Vasopressor drugs (yes) | 108 (94) | 53 (98) | 0.23b |
| Nitric oxide ventilation (yes) | 92 (80) | 41 (76) | 0.55b |
| Highest oxygenation index | 41 (31–53) | 44 (30–58) | 0.50a |
| During ECMO | |||
| ECMO mode (VV) | 20 (17) | 11 (20) | 0.72b |
| Preemptive continuous hemofiltration (yes) | 39 (34) | 23 (43) | 0.28b |
| Patients on ECMO without preemptive continuous hemofiltration | 76 | 31 | |
| Maximum RIFLE scoreb | |||
| No AKI | 34 (44) | 9 (29) | |
| Risk | 28 (37) | 6 (19) | |
| Injury | 12 (16) | 13 (42) | 0.004b |
| Failure | 2 (3) | 3 (10) | |
| ECMO duration, h | 120 (89–159) | 105 (74–155) | 0.37a |
RIFLE categories risk, injury, and failure were defined as serum creatinine>150%, >200%, and >300% of the median of age-specific reference values, respectively. RIFLE scores were only assessed among patients treated with neonatal ECMO without preemptive continuous hemofiltration. Continuous data are expressed as median (interquartile range), and categorical data are expressed as number (percentage).
a
Assessment of intergroup differences (that is, non-CKD versus CKD) using the Mann–Whitney test.
b
Assessment of intergroup differences (that is, non-CKD versus CKD) using the Pearson chi-squared or linear-by-linear association chi-squared test.