Table 1.
Participant characteristics by bicarbonate level
| Characteristic | Bicarbonate Category (mEq/L) | P for Trend | ||
|---|---|---|---|---|
| <23 (n=149) | 23–25.9 (n=814) | ≥26 (n=581) | ||
| Age, yr | 75.5±2.7 | 75.4±2.8 | 75.5±2.9 | 0.80 |
| Race, black (%) | 51 (34.2) | 263 (32.3) | 221 (38.0) | 0.08 |
| Sex, women (%) | 60 (40.3) | 366 (45.0) | 299 (51.5) | 0.003 |
| CKD (%) | 38 (25.5) | 111 (13.6) | 64 (11.0) | <0.001 |
| Diabetes (%) | 37 (25.8) | 140 (17.2) | 93 (16.0) | 0.04 |
| BMI, kg/m2 | 26.3±4.4 | 26.8±4.1 | 26.6±4.7 | 0.44 |
| Smoking (%) | <0.001a | |||
| None | 50 (33.6) | 364 (44.6) | 294 (50.6) | |
| Former | 72 (48.3) | 392 (48.2) | 261 (44.9) | |
| Current | 27 (18.1) | 58 (7.1) | 26 (4.5) | |
| Diuretic use (%) | 20 (13.4) | 135 (16.6) | 218 (37.5) | <0.001 |
| Usual gait speed, m/s | 1.17±0.20 | 1.22±0.20 | 1.19±0.19 | 0.40 |
| pH (range) | 7.40±0.04 (7.31–7.57) | 7.41±0.02 (7.31–7.48) | 7.41±0.03 (7.31–7.59) | <0.001 |
| Pco2, mmHg | 35.2±3.2 | 39.2±2.5 | 43.3±3.3 | <0.001 |
| NEAP, mEq/d | 41.2±13.1 | 39.2±10.7 | 36.4±10.9 | 0.001 |
BMI, body mass index; NEAP, net endogenous acid production.
a
P value by chi-squared test and not by trend.