Table 3.
The influence of family history of asthma on persistent and transient asthma, The Espoo Cohort Study 1991–2011, Finland
| Persistent asthma vs. no asthma | Transient asthma vs. no asthma | Heterogeneity b | |||
|---|---|---|---|---|---|
| Family history of asthma | RR | RR a | RR | RR a | Q-statistic, |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | P -value | |
| Parents or siblings with asthma | 2.62 (1.88-3.65) | 2.82 (1.99-4.00) | 1.56 (0.99-2.43) | 1.65 (1.03-2.65) | 3.20, 0.07 |
| Parents or siblings with allergic diseases | 2.11 (1.45-3.09) | 2.20 (1.48-3.28) | 0.98 (0.65-1.49) | 1.02 (0.66-1.58) | 6.50, 0.01 |
| Maternal asthma | 2.42 (1.47-3.98) | 2.50 (1.50-4.15) | 1.64 (0.89-3.04) | 1.57 (0.79-3.11) | 1.35, 0.25 |
| Maternal allergic disease | 2.31 (1.54-3.46) | 2.17 (1.40-3.37) | 1.44 (0.88-2.38) | 1.48 (0.87-2.52) | 1.18, 0.77 |
| Paternal asthma | 2.47 (1.43-4.28) | 2.70 (1.52-4.80) | 0.97 (0.39-2.40) | 1.10 (0.44-2.73) | 0.85, 0.35 |
| Paternal allergic disease | 1.13 (0.66-1.94) | 1.29 (0.75-2.22) | 1.07 (0.61-1.91) | 1.20 (0.67-2.15) | 0.03, 0.86 |
| Both parents with asthma | 6.92 (3.76-12.71) | 6.70 (3.34-13.45) | 2.64 (0.71-9.86) | 2.94 (0.80-10.87) | 4.24, 0.04 |
| Both parents with allergic disease | 3.05 (1.88-4.95) | 3.32 (2.01-5.47) | 1.07 (0.46-2.45) | 0.97 (0.39-2.40) | 5.41, 0.02 |
| Siblings with asthma only | 2.11 (1.31-3.40) | 2.33 (1.42-3.84) | 1.62 (0.85-3.09) | 1.79 (0.93-3.45) | 7.36, 0.01 |
| Siblings with allergic disease only | 1.67 (0.99-2.80) | 1.75 (1.02-3.01) | 0.57 (0.26-1.27) | 0.63 (0.28-1.41) | 4.27, 0.04 |
| Parents with asthma only | 2.41 (1.52-3.84) | 2.50 (1.54-4.06) | 1.55 (0.88-2.73) | 1.56 (0.85-2.87) | 4.29, 0.04 |
| Parents with allergic disease only | 1.84 (1.16-2.92) | 1.82 (1.12-2.97) | 1.19 (0.74-1.91) | 1.23 (0.75-2.03) | 1.20, 0.27 |
| Parents and siblings with asthma | 5.52 (3.31-9.20) | 5.97 (3.48-10.22) | 1.39 (0.45-4.32) | 1.64 (0.52-5.14) | 17.40, 0.00 |
| Parents and siblings with allergic disease | 3.13 (2.00-4.90) | 3.48 (2.18-5.56) | 1.01 (0.55-1.84) | 1.02 (0.54-1.92) | 9.40, 0.00 |
19 People excluded from the analyses due to follow-up period of less than 5 years (n = 8) or asthma relapse (n = 11).
aAdjusted for sex, age, family socioeconomic status at baseline, maternal smoking in pregnancy, SHS at the age of 0–3, mold exposure at the age of 0–3, and duration of breast-feeding.
bHeterogeneity calculated between the adjusted risk ratios of persistent and transient asthma.