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. 2014 Nov 26;13:253. doi: 10.1186/1476-4598-13-253

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© Zhang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Reverse correlation between miR-149 and AKT1 mRNA expression in human HCC tissues and cells. (A and B) Relative expression of miR-149 and AKT1 mRNA in 130 self-pairs of HCC and adjacent nonneoplastic liver tissues; (C) Spearman Correlation analysis clearly showed a negative correlation between miR-149 and AKT1 mRNA expression in HCC tissues (rs = -0.639, P < 0.001); (D) Spearman Correlation analysis clearly showed a negative correlation between miR-149 and AKT1 protein expression in HCC tissues (rs = -0.716, P < 0.001); (E and F) Relative expression of miR-149 and AKT1 mRNA HCC (HepG2) and normal liver (HL-7702) cells.