Table 2.
Comorbidity profile of the patients with dementia with Lewy bodies versus Alzheimer’s disease patients based on the chapters of the International Statistical Classification of Diseases and Related Health Problems, 10th Revision
| Chapter | Blocks | Title |
DLB |
AD |
Unadjusted |
P value a |
Adjusted |
P value b |
|---|---|---|---|---|---|---|---|---|
| (n = 634) | (n = 9,161) | OR (95% CI) | OR (95% CI) | |||||
| I |
A00 to B99 |
Certain infectious and parasitic diseases |
87 (13.7) |
1,064 (11.6) |
1.21 (0.96 to 1.53) |
0.111 |
1.25 (0.98 to 1.59) |
0.069 |
| II |
C00 to D48 |
Neoplasms |
203 (32.0) |
2,733 (29.8) |
1.11 (0.93 to 1.32) |
0.245 |
1.06 (0.88 to 1.27) |
0.541 |
| III |
D50 to D89 |
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism |
29 (4.6) |
433 (4.7) |
0.97 (0.66 to 1.42) |
0.861 |
1.01 (0.68 to 1.49) |
0.976 |
| IV |
E00 to E90 |
Endocrine, nutritional and metabolic diseases |
79 (12.5) |
1,088 (11.9) |
1.06 (0.83 to 1.35) |
0.661 |
1.16 (0.90 to 1.49) |
0.239 |
| V |
F00 to F99 |
Mental and behavioral disorders |
419 (66.1) |
3,543 (38.7) |
3.09 (2.61 to 3.66) |
<0.001 |
3.14 (2.63 to 3.75) |
<0.001 |
| VI |
G00 to G99 |
Diseases of the nervous system |
558 (88.0) |
6,508 (71.0) |
2.99 (2.34 to 3.82) |
<0.001 |
2.78 (2.15 to 3.58) |
<0.001 |
| VII |
H00 to H59 |
Diseases of the eye and adnexa |
367 (57.9) |
4,390 (47.9) |
1.49 (1.27 to 1.76) |
<0.001 |
1.69 (1.42 to 2.01) |
<0.001 |
| VIII |
H60 to H95 |
Diseases of the ear and mastoid process |
96 (15.1) |
1,462 (16.0) |
0.94 (0.75 to 1.18) |
0.586 |
0.97 (0.77 to 1.22) |
0.810 |
| IX |
I00 to I99 |
Diseases of the circulatory system |
293 (46.2) |
3,693 (40.3) |
1.27 (1.08 to 1.49) |
0.003 |
1.29 (1.08 to 1.52) |
0.004 |
| X |
J00 to J99 |
Diseases of the respiratory system |
146 (23.0) |
1,663 (18.2) |
1.35 (1.11 to 1.63) |
0.002 |
1.30 (1.06 to 1.59) |
0.010 |
| XI |
K00 to K93 |
Diseases of the digestive system |
237 (37.4) |
2,966 (32.4) |
1.25 (1.05 to 1.47) |
0.009 |
1.17 (0.98 to 1.39) |
0.082 |
| XII |
L00 to L99 |
Diseases of the skin and subcutaneous tissue |
155 (24.4) |
1,918 (20.9) |
1.22 (1.01 to 1.47) |
0.036 |
1.27 (1.05 to 1.54) |
0.016 |
| XIII |
M00 to M99 |
Diseases of the musculoskeletal system and connective tissue |
273 (43.1) |
3,732 (40.7) |
1.10 (0.93 to 1.29) |
0.250 |
1.19 (1.01 to 1.41) |
0.040 |
| XIV |
N00 to N99 |
Diseases of the genitourinary system |
233 (36.8) |
2,984 (32.6) |
1.20 (1.02 to 1.42) |
0.030 |
1.24 (1.04 to 1.47) |
0.015 |
| XV |
O00 to O99 |
Pregnancy, childbirth and the puerperium |
1 (0.2) |
2 (0.0) |
– |
– |
– |
– |
| XVI |
P00 to P96 |
Certain conditions originating in the perinatal period |
0 |
0 |
– |
– |
– |
– |
| XVII |
Q00 to Q99 |
Congenital malformations, deformations and chromosomal abnormalities |
5 (0.8) |
57 (0.6) |
1.27 (0.51 to 3.18) |
0.609 |
1.55 (0.61 to 3.98) |
0.358 |
| XVIII |
R00 to R99 |
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
460 (72.6) |
5,896 (64.4) |
1.46 (1.22 to 1.75) |
<0.001 |
1.44 (1.19 to 1.73) |
<0.001 |
| XIX |
S00 to T98 |
Injury, poisoning and certain other consequences of external causes |
369 (58.2) |
4,679 (51.1) |
1.33 (1.13 to 1.57) |
0.001 |
1.54 (1.30 to 1.83) |
<0.001 |
| XX |
V01 to Y98 |
External causes of morbidity and mortality |
0 |
1 (0.0) |
– |
– |
– |
– |
| XXI | Z00 to Z99 | Factors influencing health status and contact with health services | 523 (82.5) | 6,718 (73.3) | 1.71 (1.39 to 2.11) | <0.001 | 1.73 (1.39 to 2.16) | <0.001 |
Adjustment is made for age, sex, and Mini-Mental State Examination score. The AD group is considered the reference group. Statistically significant ORs (P < 0.05) in bold. AD, Alzheimer’s disease; CI, confidence interval; DLB, dementia with Lewy bodies; OR, odds ratio. aChi-square statistics. bBinary logistic regression model.