Table 3.
Comorbidity profile of patients with dementia with Lewy bodies (n = 634) versus Alzheimer’s disease patients (n = 9,161) within different subgroups regarding gender, cognitive level at the time of diagnosis and living place using the chapters of the International Statistical Classification of Diseases and Related Health Problems, 10th Revision
| Title | Gender | DLB (%) | AD (%) | P value | Cognition | DLB (%) | AD (%) | P value | Living place | DLB (%) | AD (%) | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Certain infectious and parasitic diseases |
Male |
14.9 |
12.5 |
0.183 |
MMSE ≥ 22 |
16.3 |
11.2 |
0.005 |
Own house |
14.3 |
11.4 |
0.038 |
| Female |
11.9 |
11.1 |
0.703 |
MMSE < 22 |
11.9 |
12.2 |
0.855 |
Nursing home |
9.3 |
15.0 |
0.188 |
|
| Neoplasms |
Male |
35.6 |
33.8 |
0.494 |
MMSE ≥ 22 |
32.8 |
31.6 |
0.652 |
Own house |
32.4 |
30.1 |
0.259 |
| Female |
26.6 |
27.7 |
0.701 |
MMSE < 22 |
31.9 |
27.9 |
0.169 |
Nursing home |
29.3 |
25.4 |
0.467 |
|
| Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism |
Male |
5.2 |
4.8 |
0.687 |
MMSE ≥ 22 |
3.6 |
4.5 |
0.447 |
Own house |
4.7 |
4.6 |
0.967 |
| Female |
3.6 |
4.7 |
0.403 |
MMSE < 22 |
5.9 |
4.8 |
0.414 |
Nursing home |
4.0 |
6.8 |
0.457 |
|
| Endocrine, nutritional and metabolic diseases |
Male |
12.8 |
10.9 |
0.262 |
MMSE ≥ 22 |
10.5 |
11.7 |
0.526 |
Own house |
12.3 |
11.8 |
0.700 |
| Female |
11.9 |
12.4 |
0.819 |
MMSE < 22 |
15.9 |
11.8 |
0.046 |
Nursing home |
13.3 |
13.5 |
0.973 |
|
| Mental and behavioral disorders |
Male |
67.3 |
37.4 |
<0.001 |
MMSE ≥ 22 |
65.7 |
40.8 |
<0.001 |
Own house |
65.5 |
38.8 |
<0.001 |
| Female |
64.3 |
39.3 |
<0.001 |
MMSE < 22 |
66.7 |
36.0 |
<0.001 |
Nursing home |
70.7 |
36.5 |
<0.001 |
|
| Diseases of the nervous system |
Male |
91.4 |
72.8 |
<0.001 |
MMSE ≥ 22 |
89.5 |
75.5 |
<0.001 |
Own house |
88.7 |
72.2 |
<0.001 |
| Female |
82.9 |
70.1 |
<0.001 |
MMSE < 22 |
86.3 |
66.8 |
<0.001 |
Nursing home |
82.7 |
52.3 |
<0.001 |
|
| Diseases of the eye and adnexa |
Male |
56.5 |
44.2 |
<0.001 |
MMSE ≥ 22 |
60.2 |
49.0 |
<0.001 |
Own house |
58.3 |
47.7 |
<0.001 |
| Female |
59.9 |
49.9 |
0.002 |
MMSE < 22 |
55.6 |
47.0 |
0.007 |
Nursing home |
54.7 |
52.0 |
0.660 |
|
| Diseases of the ear and mastoid process |
Male |
15.4 |
17.2 |
0.383 |
MMSE ≥ 22 |
17.5 |
17.1 |
0.857 |
Own house |
15.7 |
16.2 |
0.790 |
| Female |
14.7 |
15.3 |
0.794 |
MMSE < 22 |
14.1 |
14.6 |
0.819 |
Nursing home |
10.7 |
12.9 |
0.588 |
|
| Diseases of the circulatory system |
Male |
45.8 |
43.5 |
0.391 |
MMSE ≥ 22 |
43.7 |
40.8 |
0.296 |
Own house |
46.3 |
40.2 |
0.005 |
| Female |
46.8 |
38.6 |
0.009 |
MMSE < 22 |
49.6 |
39.1 |
0.001 |
Nursing home |
45.3 |
41.2 |
0.499 |
|
| Diseases of the respiratory system |
Male |
27.7 |
20.5 |
0.001 |
MMSE ≥ 22 |
22.0 |
17.6 |
0.043 |
Own house |
22.9 |
18.0 |
0.004 |
| Female |
15.9 |
16.9 |
0.677 |
MMSE < 22 |
24.4 |
18.6 |
0.018 |
Nursing home |
24.0 |
20.1 |
0.438 |
|
| Diseases of the digestive system |
Male |
41.6 |
37.0 |
0.079 |
MMSE ≥ 22 |
36.7 |
34.3 |
0.357 |
Own house |
37.7 |
32.7 |
0.013 |
| Female |
31.0 |
29.9 |
0.721 |
MMSE < 22 |
38.9 |
30.3 |
0.003 |
Nursing home |
34.7 |
27.9 |
0.229 |
|
| Diseases of the skin and subcutaneous tissue |
Male |
24.3 |
20.2 |
0.057 |
MMSE ≥ 22 |
25.3 |
22.5 |
0.230 |
Own house |
24.7 |
21.1 |
0.043 |
| Female |
24.6 |
21.3 |
0.217 |
MMSE < 22 |
24.1 |
19.3 |
0.056 |
Nursing home |
22.7 |
18.6 |
0.397 |
|
| Diseases of the musculoskeletal system and connective tissue |
Male |
39.8 |
36.1 |
0.157 |
MMSE ≥ 22 |
41.3 |
42.9 |
0.555 |
Own house |
42.9 |
41.0 |
0.371 |
| Female |
48.0 |
43.2 |
0.132 |
MMSE < 22 |
45.6 |
38.5 |
0.022 |
Nursing home |
44.0 |
37.5 |
0.280 |
|
| Diseases of the genitourinary system |
Male |
36.4 |
32.1 |
0.093 |
MMSE ≥ 22 |
38.0 |
33.6 |
0.108 |
Own house |
38.3 |
32.6 |
0.005 |
| Female |
37.3 |
32.8 |
0.138 |
MMSE < 22 |
35.6 |
31.1 |
0.132 |
Nursing home |
25.3 |
32.6 |
0.205 |
|
| Pregnancy, childbirth and the puerperium |
Male |
– |
– |
– |
MMSE ≥ 22 |
0.3 |
0 |
0.062 |
Own house |
0.2 |
0 |
0.061 |
| Female |
0.4 |
0 |
0.117 |
MMSE < 22 |
0 |
0.1 |
1 |
Nursing home |
0 |
0.4 |
1 |
|
| Certain conditions originating in the perinatal period |
Male |
0 |
0 |
– |
MMSE ≥ 22 |
0 |
0 |
– |
Own house |
0 |
0 |
– |
| Female |
0 |
0 |
– |
MMSE < 22 |
0 |
0 |
– |
Nursing home |
0 |
0 |
– |
|
| Congenital malformations, deformations and chromosomal abnormalities |
Male |
1.0 |
0.6 |
0.300 |
MMSE ≥ 22 |
0.9 |
0.6 |
0.464 |
Own house |
0.7 |
0.5 |
0.545 |
| Female |
0.4 |
0.6 |
1 |
MMSE < 22 |
0.7 |
0.4 |
0.349 |
Nursing home |
1.3 |
2.1 |
1 |
|
| Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Male |
72.8 |
66.9 |
0.020 |
MMSE ≥ 22 |
74.1 |
67.2 |
0.010 |
Own house |
72.3 |
64.5 |
<0.001 |
| Female |
72.2 |
63.0 |
0.003 |
MMSE < 22 |
71.5 |
61.3 |
0.001 |
Nursing home |
74.7 |
62.7 |
0.043 |
|
| Injury, poisoning and certain other consequences of external causes |
Male |
50.8 |
45.1 |
0.034 |
MMSE ≥ 22 |
59.6 |
49.2 |
<0.001 |
Own house |
58.3 |
50.2 |
<0.001 |
| Female |
69.4 |
54.3 |
<0.001 |
MMSE < 22 |
56.7 |
53.5 |
0.312 |
Nursing home |
57.3 |
64.8 |
0.206 |
|
| External causes of morbidity and mortality |
Male |
0 |
0 |
– |
MMSE ≥ 22 |
0 |
0 |
– |
Own house |
0 |
0 |
– |
| Female |
0 |
0 |
– |
MMSE < 22 |
0 |
0 |
– |
Nursing home |
0 |
0 |
– |
|
| Factors influencing health status and contact with health services | Male |
81.4 |
73.0 |
<0.001 |
MMSE ≥ 22 |
84.3 |
76.8 |
0.001 |
Own house |
83.2 |
73.8 |
<0.001 |
| Female | 84.1 | 73.5 | <0.001 | MMSE < 22 | 81.1 | 69.8 | <0.001 | Nursing home | 77.3 | 65.8 | 0.047 |
Statistically significant differences (P < 0.05) in bold. Univariate comparisons were performed using either the chi-square or Fisher’s exact test wherever appropriate. AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; MMSE, Mini-Mental State Examination.