Table 4.
Comorbidity profile of the patients with dementia with Lewy bodies versus Alzheimer’s disease patients based on the Royal College of Surgeons Charlson Score indicating International Classification of Disease, 10th revision codes for 14 disease categories
| Disease category |
DLB |
AD |
Unadjusted |
P value a |
Adjusted |
P value b |
|---|---|---|---|---|---|---|
| (n = 634) | (n = 9,161) | OR (95% CI) | OR (95% CI) | |||
| Myocardial infarction |
34 (5.4) |
532 (5.8) |
0.92 (0.64 to 1.31) |
0.643 |
0.85 (0.59 to 1.22) |
0.372 |
| Congestive cardiac failure |
38 (6.0) |
458 (5.0) |
1.21 (0.86 to 1.70) |
0.270 |
1.21 (0.85 to 1.73) |
0.282 |
| Peripheral vascular disease |
15 (2.4) |
271 (3.0) |
0.79 (0.47 to 1.34) |
0.392 |
0.77 (0.45 to 1.31) |
0.335 |
| Cerebrovascular disease |
103 (16.2) |
912 (10.0) |
1.75 (1.40 to 2.19) |
<0.001 |
1.74 (1.38 to 2.19) |
<0.001 |
| Chronic pulmonary disease |
27 (4.3) |
480 (5.2) |
0.80 (0.54 to 1.20) |
0.281 |
0.88 (0.59 to 1.31) |
0.525 |
| Rheumatological disease |
12 (1.9) |
286 (3.1) |
0.60 (0.33 to 1.07) |
0.081 |
0.64 (0.35 to 1.19) |
0.160 |
| Liver disease |
4 (0.6) |
48 (0.5) |
1.20 (0.43 to 3.35) |
0.578 |
1.13 (0.40 to 3.19) |
0.818 |
| Diabetes mellitus |
26 (4.1) |
481 (5.3) |
0.77 (0.52 to 1.15) |
0.206 |
0.73 (0.48 to 1.11) |
0.145 |
| Hemiplegia or paraplegia |
0 |
19 (0.2) |
– |
0.631 |
– |
0.998 |
| Renal disease |
11 (1.7) |
98 (1.1) |
1.63 (0.87 to 3.06) |
0.123 |
1.57 (0.83 to 2.97) |
0.167 |
| Any malignancy |
94 (14.8) |
1283 (14.0) |
1.07 (0.85 to 1.34) |
0.565 |
0.96 (0.75 to 1.21) |
0.707 |
| Metastatic solid tumor |
2 (0.3) |
74 (0.8) |
0.39 (0.09 to 1.59) |
0.239 |
0.42 (0.10 to 1.74) |
0.235 |
| AIDS/HIV infection |
0 |
1 (0.0) |
– |
– |
– |
– |
| Total Charlson score | 1.52 (0.85) | 1.33 (0.89) | 1.25 (1.15 to 1.36) | <0.001 | 1.22 (1.12 to 1.33) | <0.001 |
Data presented as mean (standard deviation). Adjustment is made for age, sex, and Mini-Mental State Examination score. The AD group is considered the reference group. The dementia category of the original Charlson scoring is not reported here because the whole study population is dementia patients in our study. Statistically significant ORs (P < 0.05) in bold. AD, Alzheimer’s disease; CI, confidence interval; DLB, dementia with Lewy bodies; OR, odds ratio. aChi-square statistics. bBinary logistic regression model.