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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Proteomics. 2012 May;12(10):1527–1546. doi: 10.1002/pmic.201100599

Figure 1. Modular Protein Interaction Domains recognize short linear peptide motifs.

Figure 1

(A) Phosphorylation on serines (pSer), threonines (pThr), and tyrosines (pTyr) can be recognized by a subset of specialized PIDs. (B) Post-translational modifications on lysine by methylation (Me-Lys) mediate interactions with a large set of interaction modules whereas lysine acetylation (Ac-Lys) and arginine methylation (Me-Arg) are restricted to only Bromo and Tudor domains, respectively. (C) Modular PIDs that recognize short linear motifs. (X, represents any natural amino; ϕ, hydrophobic amino acids; -COOH, carboxyl terminus of amino acids)