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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Proteomics. 2012 May;12(10):1527–1546. doi: 10.1002/pmic.201100599

Figure 2. Protein domain interactions in time and space.

Figure 2

(A) Protein interactions domains (PIDs) (gray shapes) can coordinate multiple different interactions partners (oval shapes) in a temporal manner. For example, temporal phosphorylation of substrates by protein kinases may influence the time dependent protein domain interactions. The cellular context plays an important role in determine PIDs in specific cell types with co-expressed ligands (B) and spatial localization within the cell (C). Multiple PIDs can bind a single ligand (D) and vice versa, a single PID can recognize multiple ligands as PIDs coordinate transient protein-protein interactions (E).