Figure 3.

Oscillatory model for regulation of motility in M. xanthus. This model depicts relative protein activities in the absence of an extracellular signal. (a) The sequential order of cyclic protein activity in this model beginning with FrzCD. (b) Activity of FrzCD (red) then FrzE (yellow) lead to the activation of FrzZ (green) and FrzG (orange) with FrzZ the most downstream component of the Frz pathway. (c) The Mgl components also show oscillatory activity. The peak of MglA activity (dark blue) corresponds to when MglA is changing cell poles, whereas the broad peak of MglB activity (light blue) corresponds to when the major cluster of MglB is localized to the lagging pole and the cell is moving forward. (d) Activity of AglZ (gray) and FrzS (purple), which regulate the A- and S-motility systems, respectively, are coordinated with activity corresponding to when the proteins are changing cell poles with each ∼ 6 min oscillation. To see this figure in color, go online.