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The origin of SH2 domain families. (A) The presence or absence of SH2 families across organisms in Unikonta. (*) The cnidarian H. magnipapillata contains SH2 families absent in N. vectensis (green circles) (B) The first appearance of each of the 38 SH2 families is noted with the architecture of each protein represented in domain form (see fig. S4 for the complete key to the domains).
