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. 2014 Nov 2;6(9):70. doi: 10.1186/s13195-014-0070-5

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Copyright © 2014 Satoh et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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PLD3 immunoreactivity in Alzheimer’s disease brains (II). PLD3 immunoreactivity was studied in Alzheimer’s disease brains by double-labeling immunohistochemistry. (a) Frontal cortex, PLD3 (brown), amyloid beta (Aβ; red), colocalization of PLD3 and Aβ (arrows). (b) Frontal cortex, PLD3 (brown), GFAP (red), reactive astrocytes do not express PLD3. (c) Frontal cortex, PLD3 (brown), CD68 (red), activated microglia do not express PLD3. (d) Hippocampal CA1 region, PLD3 (brown), AT8-tau (red), colocalization of neurofibrillary tangles and PLD3 (arrowheads). PLD, phospholipase D.