Table 1.
Demographic profile of the cases examined in the present study
| Case number | IHC | qPCR/WB | Cause of death | Brain weight (g) | Postmortem interval (hours) | Braak staging (amyloid deposition/neurofibrillary degeneration) | p.V232M variant | c.1326G > A variant |
|---|---|---|---|---|---|---|---|---|
| NC1 |
+ |
+ |
Acute myocardial infarction |
1,130 |
1.4 |
A/II |
V/V |
G/G |
| NC2 |
+ |
+ |
Acute myocardial infarction |
1,350 |
1.6 |
0/II |
V/V |
G/G |
| NC3 |
+ |
+ |
Lung cancer |
1,060 |
3.9 |
A/II |
V/V |
G/G |
| NC4 |
+ |
+ |
Dissecting aortic aneurysm |
1,400 |
4.8 |
A/I |
V/V |
G/G |
| AD1 |
+ |
+ |
Pneumonia |
1,000 |
1.1 |
C/VI |
V/V |
G/G |
| AD2 |
+ |
+ |
Pneumonia |
1,230 |
14 |
C/VI |
V/V |
G/G |
| AD3 |
+ |
+ |
Pneumonia |
1,220 |
10.5 |
C/VI |
V/V |
G/G |
| AD4 |
+ |
+ |
Pneumonia |
1,240 |
8.1 |
C/VI |
V/V |
G/G |
| AD5 |
ND |
+ |
Lung cancer |
1,090 |
4.5 |
C/VI |
V/V |
G/G |
| AD6 |
+ |
+ |
Pulmonary infarction |
840 |
3 |
C/VI |
V/V |
G/G |
| AD7 |
ND |
+ |
Respiratory failure by aspiration |
1,200 |
3.8 |
B/IV |
V/V |
G/G |
| AD8 |
+ |
ND |
Pneumonia |
1,060 |
8 |
C/VI |
ND |
ND |
| AD9 |
+ |
ND |
Pneumonia |
970 |
NA |
C/VI |
ND |
ND |
| AD10 |
+ |
ND |
Pneumonia |
870 |
1 |
C/VI |
ND |
ND |
| AD11 |
+ |
ND |
Lung cancer |
1,125 |
14.5 |
C/VI |
ND |
ND |
| AD12 |
+ |
ND |
Multiple organ failure |
775 |
13 |
C/VI |
ND |
ND |
| PD1 |
ND |
+ |
Pneumonia |
1,330 |
9.5 |
B/IV |
V/V |
G/G |
| PD2 |
+ |
+ |
Pneumonia |
1,130 |
2.5 |
B/II |
V/V |
G/G |
| PD3 |
+ |
+ |
Respiratory failure by aspiration |
910 |
2.5 |
B/II |
V/V |
G/G |
| PD4 |
ND |
+ |
Colon cancer |
1,430 |
4 |
A/I |
V/V |
G/G |
| PD5 |
+ |
ND |
Pneumonia |
1,320 |
9.3 |
C/III |
ND |
ND |
| ALS1 |
+ |
+ |
Respiratory failure |
1,480 |
10.5 |
0/0 |
V/V |
G/G |
| ALS2 |
+ |
+ |
Respiratory failure |
1,090 |
1.3 |
0/I |
V/V |
G/G |
| ALS3 |
+ |
+ |
Respiratory failure |
1,560 |
3 |
0/I |
V/V |
G/G |
| ALS4 |
+ |
+ |
Respiratory failure |
1,320 |
10 |
0/II |
V/V |
G/G |
| ALS5 |
ND |
+ |
Respiratory failure |
1,360 |
2.5 |
B/I |
V/V |
G/G |
| ALS6 |
ND |
+ |
Respiratory failure |
1,600 |
13 |
B/I |
V/V |
G/G |
| MSA1 |
+ |
ND |
Pneumonia, septicemia |
1,040 |
1.5 |
0/I |
ND |
ND |
| MSA2 | + | ND | Pneumonia | 1,090 | 12 | A/I | ND | ND |
Demographic profile of the cases processed for immunohistochemistry (IHC), quantitative reverse transcription-polymerase chain reaction (qPCR), and western blot (WB) is shown with the case number, the cause of death, brain weight, the postmortem interval, the Braak Staging (amyloid deposition/neurofibrillary degeneration), p.Val232Met variant of rs145999145, and c.1326G > A variant of rs4819. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; MSA, multiple system atrophy; NA, information not available; NC, non-neurological causes; ND, not determined; PD, Parkinson’s disease.