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. 2014 Nov 4;18(6):601. doi: 10.1186/s13054-014-0601-2

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© Ralib et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Risk assessment plots showing the additional value of individual biomarkers compared with the reference model for prediction of the composite of mortality or dialysis. The reference model included the modified acute physiological and chronic health evaluation (APACHE) II score (without creatinine score), and AKI₂₄ (present or absent). The new models comprised the reference model plus peak (A) urinary neutrophil gelatinase-associated lipocalin (NGAL), (B) urinary albumin (C) plasma cystatin C, or (D) urinary π-glutathione-S-transferase (GST) within 24 h. Event curves (squares) are sensitivity versus calculated risk. Non-event curves (circles) are 1-specificity versus calculated risk.