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Combined PDE-5 and ET A inhibition suppresses pulmonary hypertension in SU-Hx rats. (A–B) Mean pulmonary arterial pressure (mPAP) and PA pulse pressure (PAPP) were measured invasively at study endpoint. (C) The partial pressure of oxygen in arterial blood was significantly increased by TAD/AMB. Values in all groups are higher than normal due to ventilation of animals with 100% O2 during pressure-volume analyses.
