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. 2014 Nov 26;12:314. doi: 10.1186/s12967-014-0314-y

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© Cavasin et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Combined PDE-5 and ET _A inhibition blocks RV hypertrophy and pro-hypertrophic calcineurin signaling. RV hypertrophy, as determined by comparing weights of RV vs. LV + septum (S) (A) or RV mass to tibia length ratio (B) was significantly reduced by combined TAD/AMB treatment. (C) LV hypertrophy was not observed in the model. *P < 0.05 vs. normoxia; †P < 0.05 vs. SU-Hx + vehicle (D) Immunoblotting revealed normalization of RCAN1 expression in RVs of animals treated with TAD/AMB, indicating suppression of calcineurin signaling. Calnexin served as a loading control. (E) Elevated RCAN1 expression was observed in LVs of some SU-Hx rats.