Figure 27.

Urinary Kim-1 excretion, expressed as Kim-1 (ng/kg/24 h), for the following groups: (A) untreated age-matched control rats, (B) rats treated with 44 po once daily at a dose of 170.7 μmol/kg/day × 28 days, (C) rats given Exjade po once daily at a dose of 384 μmol/kg/day, (D) rats given 44 po once daily at a dose of 384 μmol/kg/day × 10 days, (E) rats given deferitrin (26) po twice daily at a dose of 237 μmol/kg/dose (474 μmol/kg/day) × 7 days, and (F) rats given 44 po twice daily at a dose of 237 μmol/kg/dose (474 μmol/kg/day) × 7 days. Note that none of the rats survived the planned 10 day exposure to Exjade. For groups A–D and F, n = 5; for group E, n = 3.