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. 2014 Sep 10;57(22):9259–9291. doi: 10.1021/jm500828f

Scheme 2. Synthesis of 36.

Scheme 2

Reagents and conditions: (a) 60% NaH (2.0 equiv), DMSO, 70%; (b) CH3OH(aq), pH 6, 70 °C, 16 h, 90%.