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. 2014 Sep 10;57(22):9259–9291. doi: 10.1021/jm500828f

Scheme 3. Synthesis of (S)-4,5-Dihydro-2-[2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic Acid (44) and Its Ethyl Ester (43).

Scheme 3

Reagents and conditions: (a) K2CO3 (1.1 equiv), acetone, reflux, 2 days, 73%; (c) 50% NaOH(aq) (13 equiv), CH3OH, 80%.